Separate sexes and the mitochondrial theory of ageing.

  title={Separate sexes and the mitochondrial theory of ageing.},
  author={John F Allen},
  journal={Journal of theoretical biology},
  volume={180 2},
  • John F Allen
  • Published 1996 in Journal of theoretical biology
An hypothesis is presented by which gamete specialization resolves a conflict between the function and replication of mitochondria. The function of mitochondria is to synthesize ATP by oxidative phosphorylation, which is coupled to respiratory electron transport. This requires a mitochondrial genetic system. However, "incorrect" electron transfers produce free radicals that cause mutation, and the frequency of these events is increased by mutation. Mitochondrial function is therefore… CONTINUE READING


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