Separate roles of structured and unstructured regions of Y-family DNA polymerases.

@article{Ohmori2009SeparateRO,
  title={Separate roles of structured and unstructured regions of Y-family DNA polymerases.},
  author={Haruo Ohmori and Tomo Hanafusa and Eiji Ohashi and Cyrus Vaziri},
  journal={Advances in protein chemistry and structural biology},
  year={2009},
  volume={78},
  pages={99-146}
}
All organisms have multiple DNA polymerases specialized for translesion DNA synthesis (TLS) on damaged DNA templates. Mammalian TLS DNA polymerases include Pol eta, Pol iota, Pol kappa, and Rev1 (all classified as "Y-family" members) and Pol zeta (a "B-family" member). Y-family DNA polymerases have highly structured catalytic domains; however, some of these proteins adopt different structures when bound to DNA (such as archaeal Dpo4 and human Pol kappa), while others maintain similar structures… CONTINUE READING

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