Separate proteolipid protein/DM20 enhancers serve different lineages and stages of development.

@article{Tuason2008SeparatePP,
  title={Separate proteolipid protein/DM20 enhancers serve different lineages and stages of development.},
  author={Maria Clarita Tuason and Ali Rastikerdar and Tanja Kuhlmann and C{\'e}cile Goujet-Zalc and Bernard Zalc and Samar Dib and Hana C H Friedman and Alan Peterson},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2008},
  volume={28 27},
  pages={6895-903}
}
The gene encoding DM20 emerged in cartilaginous fish, descending from a bilaterian ancestor of the M6 proteolipid gene family. Its proteolipid protein (PLP) isoform appeared in amphibians, contains an additional 35 amino acids, and, in the mammalian CNS, is the dominant myelin protein in which it confers an essential neuroprotective function. During development, the DM20 isoform is prominent in a number of tissues, and plp/DM20 transcripts are detected in multiple progenitor populations… CONTINUE READING
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