Separate nuclear import pathways converge on the nucleoporin Nup153 and can be dissected with dominant-negative inhibitors

@article{Shah1998SeparateNI,
  title={Separate nuclear import pathways converge on the nucleoporin Nup153 and can be dissected with dominant-negative inhibitors},
  author={Sundeep Shah and Douglass J. Forbes},
  journal={Current Biology},
  year={1998},
  volume={8},
  pages={1376-1386}
}
BACKGROUND Proteins generally enter or exit the nucleus as cargo of one of a small family of import and export receptors. These receptors bear distant homology to importin beta, a subunit of the receptor for proteins with classical nuclear localisation sequences (NLSs). To understand the mechanism of nuclear transport, the next question involves identifying the nuclear pore proteins that interact with the different transport receptors as they dock at the pore and translocate through it… CONTINUE READING
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