• Corpus ID: 14987481

Separate mechanisms for procarbazine spermatotoxicity and anticancer activity.

  title={Separate mechanisms for procarbazine spermatotoxicity and anticancer activity.},
  author={Martin Horstman and Gary G. Meadows and Garold S. Yost},
  journal={Cancer research},
  volume={47 6},
Procarbazine causes dose-dependent decreases in sperm count after a single i.p. injection in (C57BL/6 X DBA/2)F1 male mice. Two antioxidants, N-acetylcysteine and sodium ascorbate, administered with equimolar doses of procarbazine decreased the spermatotoxicity of procarbazine. At the highest doses of procarbazine (400 mg/kg) that caused a 56% decrease in sperm count, equimolar doses of N-acetylcysteine coadministered with procarbazine caused only a 17% decrease in sperm count, and equimolar… 

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