Separate domains of Rev1 mediate two modes of DNA damage bypass in mammalian cells.

  title={Separate domains of Rev1 mediate two modes of DNA damage bypass in mammalian cells.},
  author={Jacob G. Jansen and Anastasia Tsaalbi-Shtylik and Giel Hendriks and Himabindu Gali and Ayal Hendel and Fredrik Johansson and Klaus Erixon and Zvi Livneh and L. H. Mullenders and Lajos Haracska and Niels de Wind},
  journal={Molecular and cellular biology},
  volume={29 11},
The Y family DNA polymerase Rev1 has been proposed to play a regulatory role in the replication of damaged templates. To elucidate the mechanism by which Rev1 promotes DNA damage bypass, we have analyzed the progression of replication on UV light-damaged DNA in mouse embryonic fibroblasts that contain a defined deletion in the N-terminal BRCT domain of Rev1 or that are deficient for Rev1. We provide evidence that Rev1 plays a coordinating role in two modes of DNA damage bypass, i.e., an early… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.


Publications citing this paper.
Showing 1-10 of 45 extracted citations


Publications referenced by this paper.
Showing 1-10 of 68 references

Re - duced efficiency and increased mutagenicity of translesion DNA synthesis across a TT cyclobutane pyrimidine dimer , but not a TT 6 - 4 photoproduct , in human cells lacking DNA polymerase eta

  • Y. Kubota, H. Iwasaki
  • DNA Repair
  • 2009

Similar Papers

Loading similar papers…