Separate domains of Rev1 mediate two modes of DNA damage bypass in mammalian cells.

@article{Jansen2009SeparateDO,
  title={Separate domains of Rev1 mediate two modes of DNA damage bypass in mammalian cells.},
  author={Jacob G. Jansen and Anastasia Tsaalbi-Shtylik and Giel Hendriks and Himabindu Gali and Ayal Hendel and Fredrik Johansson and Klaus Erixon and Zvi Livneh and L. H. Mullenders and Lajos Haracska and Niels de Wind},
  journal={Molecular and cellular biology},
  year={2009},
  volume={29 11},
  pages={3113-23}
}
The Y family DNA polymerase Rev1 has been proposed to play a regulatory role in the replication of damaged templates. To elucidate the mechanism by which Rev1 promotes DNA damage bypass, we have analyzed the progression of replication on UV light-damaged DNA in mouse embryonic fibroblasts that contain a defined deletion in the N-terminal BRCT domain of Rev1 or that are deficient for Rev1. We provide evidence that Rev1 plays a coordinating role in two modes of DNA damage bypass, i.e., an early… CONTINUE READING

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