Separate cis-acting elements determine the expression of mouse Dbx gene in multiple spatial domains of the central nervous system

@article{Lu1996SeparateCE,
  title={Separate cis-acting elements determine the expression of mouse Dbx gene in multiple spatial domains of the central nervous system},
  author={Sangwei Lu and Cooduvalli S. Shashikant and Frank H. Ruddle},
  journal={Mechanisms of Development},
  year={1996},
  volume={58},
  pages={193-202}
}
Dbx, a divergent homeobox gene, is expressed in a regionally restricted pattern in the developing mouse central nervous system (CNS). In order to understand its spatial regulation, we have isolated a cis-regulatory region using a reporter gene analytical approach in transgenic mice. A 5.7 kb DNA fragment that contains the transcriptional start site of the Dbx gene is sufficient to direct the expression of the transgene to various domains of the CNS in a temporally regulated fashion. The… CONTINUE READING
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