Separate assessment of intestinal and hepatic first-pass effects using a rat model with double cannulation of the portal and jugular veins.

@article{Murakami2003SeparateAO,
  title={Separate assessment of intestinal and hepatic first-pass effects using a rat model with double cannulation of the portal and jugular veins.},
  author={Tsuyoshi Murakami and Machiko Nakanishi and Takeo Yoshimori and Noboru Okamura and Ryo Norikura and Kenji Mizojiri},
  journal={Drug metabolism and pharmacokinetics},
  year={2003},
  volume={18 4},
  pages={
          252-60
        }
}
To separately assess intestinal and hepatic first-pass effects with absorption ratio data, we have established an experimental model of rats double-cannulated into the portal and jugular veins. The model allows us to take blood samples simultaneously from conscious rats that have recovered from surgical damage. Double cannulation did not alter the physiological and hematological conditions. Moreover, the plasma concentration profiles of unchanged drug following oral and intravenous… CONTINUE READING
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