Separable roles for Exonuclease I in meiotic DNA double-strand break repair.

@article{Keelagher2011SeparableRF,
  title={Separable roles for Exonuclease I in meiotic DNA double-strand break repair.},
  author={Rebecca E Keelagher and Victoria E. Cotton and Alastair S. H. Goldman and Rhona H. Borts},
  journal={DNA repair},
  year={2011},
  volume={10 2},
  pages={126-37}
}
Exo1 is a member of the Rad2 protein family and possesses both 5'-3' exonuclease and 5' flap endonuclease activities. In addition to performing a variety of functions during mitotic growth, Exo1 is also important for the production of crossovers during meiosis. However, its precise molecular role has remained ambiguous and several models have been proposed to account for the crossover deficit observed in its absence. Here, we present physical evidence that the nuclease activity of Exo1 is… CONTINUE READING