Separable noradrenergic and dopaminergic regulation of prepulse inhibition in rats: implications for predictive validity and Tourette Syndrome

Abstract

Startle inhibition by lead stimuli (prepulse inhibition, “PPI”), and the disruption of this process by dopamine agonists and N-methyl-d-aspartate (NMDA) antagonists, are used in predictive models for antipsychotic development. PPI is also disrupted by the norepinephrine α-1 agonist, cirazoline, and the PPI-disruptive effects of the indirect dopamine agonist… (More)
DOI: 10.1007/s00213-006-0374-7

Topics

6 Figures and Tables

Cite this paper

@article{Swerdlow2006SeparableNA, title={Separable noradrenergic and dopaminergic regulation of prepulse inhibition in rats: implications for predictive validity and Tourette Syndrome}, author={Neal R. Swerdlow and Michele J. Bongiovanni and Laura S Tochen and Jody M. Shoemaker}, journal={Psychopharmacology}, year={2006}, volume={186}, pages={246-254} }