Separable features of visual cortical plasticity revealed by N-methyl-D-aspartate receptor 2A signaling.

@article{Fagiolini2003SeparableFO,
  title={Separable features of visual cortical plasticity revealed by N-methyl-D-aspartate receptor 2A signaling.},
  author={Michela Fagiolini and Hiroyuki Katagiri and Hiroyuki Miyamoto and Hisashi Mori and Seth G.N Grant and Masayoshi Mishina and Takao K Hensch},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2003},
  volume={100 5},
  pages={2854-9}
}
How individual receptive field properties are formed in the maturing sensory neocortex remains largely unknown. The shortening of N-methyl-d-aspartate (NMDA) receptor currents by 2A subunit (NR2A) insertion has been proposed to delimit the critical period for experience-dependent refinement of circuits in visual cortex. In mice engineered to maintain prolonged NMDA responses by targeted deletion of NR2A, the sensitivity to monocular deprivation was surprisingly weakened but restricted to the… CONTINUE READING
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