Sentinel p16INK4a+ cells in the basement membrane form a reparative niche in the lung

@article{Reyes2020SentinelPC,
  title={Sentinel p16INK4a+ cells in the basement membrane form a reparative niche in the lung},
  author={Nabora S Reyes and Maria Krasilnikov and Nancy C. Allen and Jin Young Lee and Ben Hyams and Minqi Zhou and Supriya Ravishankar and Monica Cassandras and Chaoqun Wang and Imran Khan and Peri Matatia and Yoshikazu Johmura and Ari B. Molofsky and Michael Matthay and Makoto Nakanishi and Dean Sheppard and Judith Campisi and Tien Peng},
  journal={bioRxiv},
  year={2020}
}
Senescent cells are recognized drivers of aging-related decline in organ function, but deciphering the biology of senescence in vivo has been hindered by the paucity of tools to track and isolate senescent cells in tissues1–4. Deleting senescent cells from transgenic murine models have demonstrated therapeutic benefits in numerous age-related diseases5–11, but the identity, behavior, and function of the senescent cells deleted in vivo remain elusive. We engineered an ultra-sensitive reporter of… 

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