Sentinel Lymph Node–Targeted Therapy by Oncolytic Sendai Virus Suppresses Micrometastasis of Head and Neck Squamous Cell Carcinoma in an Orthotopic Nude Mouse Model

  title={Sentinel Lymph Node–Targeted Therapy by Oncolytic Sendai Virus Suppresses Micrometastasis of Head and Neck Squamous Cell Carcinoma in an Orthotopic Nude Mouse Model},
  author={Yuya Tanaka and Koji Araki and Shingo Tanaka and Yoshihiro Miyagawa and Hiroshi Suzuki and Daisuke Kamide and Masayuki Tomifuji and Kosuke Uno and Eiko Kimura and Taku Yamashita and Yasuji Ueda and Akihiro Shiotani},
  journal={Molecular Cancer Therapeutics},
  pages={1430 - 1438}
In clinical N0 (cN0) cases with head and neck squamous cell carcinoma (HNSCC), a treatment selection is still controversial: elective neck dissection or watchful waiting. We focused on sentinel lymph node (SLN)–targeted therapy using the urokinase-type plasminogen activator (uPA)-dependent oncolytic Sendai virus “BioKnife.” The objectives of this study were to investigate BioKnife migration into SLNs and elucidate its antitumor effect on lymph node metastases (LNM). We established an orthotopic… 

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