Sensory renal innervation: a kidney-specific firing activity due to a unique expression pattern of voltage-gated sodium channels?

@article{Freisinger2013SensoryRI,
  title={Sensory renal innervation: a kidney-specific firing activity due to a unique expression pattern of voltage-gated sodium channels?},
  author={Wolfgang Freisinger and Johannes Schatz and Tilmann Ditting and Angelika Lampert and Sonja Heinlein and Nena Lale and Roland E Schmieder and Roland Veelken},
  journal={American journal of physiology. Renal physiology},
  year={2013},
  volume={304 5},
  pages={F491-7}
}
Sensory neurons with afferent axons from the kidney are extraordinary in their response to electrical stimulation. More than 50% exhibit a tonic firing pattern, i.e., sustained action potential firing throughout depolarizing, pointing to an increased excitability, whereas nonrenal neurons show mainly a phasic response, i.e., less than five action potentials. Here we investigated whether these peculiar firing characteristics of renal afferent neurons are due to differences in the expression of… CONTINUE READING