Sensory neurons from Nf1 haploinsufficient mice exhibit increased excitability.

  title={Sensory neurons from Nf1 haploinsufficient mice exhibit increased excitability.},
  author={Yue Wang and Grant D. Nicol and David W Clapp and Cynthia M. Hingtgen},
  journal={Journal of neurophysiology},
  volume={94 6},
Neurofibromatosis type 1 (NF1) is a common genetic disorder characterized by tumor formation. People with NF1 also can experience more intense painful responses to stimuli, such as minor trauma, than normal. NF1 results from a heterozygous mutation of the NF1 gene, leading to decreased levels of neurofibromin, the protein product of the NF1 gene. Neurofibromin is a guanosine triphosphatase activating protein (GAP) for Ras and accelerates the conversion of active Ras-GTP to inactive Ras-GDP… CONTINUE READING


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