Sensory neurons and schwann cells respond to oxidative stress by increasing antioxidant defense mechanisms.

@article{Vincent2009SensoryNA,
  title={Sensory neurons and schwann cells respond to oxidative stress by increasing antioxidant defense mechanisms.},
  author={Andrea M. Vincent and Koichi Kato and Lisa L. McLean and Mary E. Soules and Eva L. Feldman},
  journal={Antioxidants & redox signaling},
  year={2009},
  volume={11 3},
  pages={425-38}
}
Elevated blood glucose is a key initiator of mechanisms leading to diabetic neuropathy. Increases in glucose induce acute mitochondrial oxidative stress in dorsal root ganglion (DRG) neurons, the sensory neurons normally affected in diabetic neuropathy, whereas Schwann cells are largely unaffected. We propose that activation of an antioxidant response in DRG neurons would prevent glucose-induced injury. In this study, mild oxidative stress (1 microM H2O2) leads to the activation of the… CONTINUE READING

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