Sensory nerves, neurogenic inflammation and pain: missing components of alternative irritation strategies? A review and a potential strategy.

The eyes and skin are highly innervated by sensory nerves; stimulation of these nerves by irritants may give rise to neurogenic inflammation, leading to sensory irritation and pain. Few in vitro models of neurogenic inflammation have been described in conjunction with alternative skin and eye irritation methods, despite the fact that the sensory innervation… (More)