Sensory nerve- and neuropeptide-mediated relaxation responses in airways of Sprague-Dawley rats.

@article{Szarek1995SensoryNA,
  title={Sensory nerve- and neuropeptide-mediated relaxation responses in airways of Sprague-Dawley rats.},
  author={John L Szarek and Nick Meader Kristel King Alexis Llewellyn Gill Norman J Stewart and Beverly Spurlock and Claudia Schneider},
  journal={Journal of applied physiology},
  year={1995},
  volume={78 5},
  pages={1679-87}
}
We examined the role of sensory nerves in mediating nonadrenergic inhibitory responses in airway segments isolated from male Sprague-Dawley rats. In the presence of adrenergic blockade, capsaicin (Cap; 1 microM) elicited marked relaxation responses in isolated bronchi precontracted with bethanechol (Beth). Cap-induced inhibitory responses were unaffected by tetrodotoxin (TTX), were attenuated by incubation of the airway with indomethacin (Indo), phosphoramidon, or RP-67580, but were abolished… CONTINUE READING