Sensory input to the central nervous system from the lungs and airways: A prominent role for purinergic signalling via P2X2/3 receptors.

@article{Adriaensen2015SensoryIT,
  title={Sensory input to the central nervous system from the lungs and airways: A prominent role for purinergic signalling via P2X2/3 receptors.},
  author={Dirk Adriaensen and Inge Brouns and Jean-Pierre Timmermans},
  journal={Autonomic neuroscience : basic & clinical},
  year={2015},
  volume={191},
  pages={39-47}
}
Specific subpopulations of lung-related primary afferent neurons in dorsal root and vagal sensory ganglia have been reported to express P2X2 and P2X3 receptors both in the neuronal cell bodies and in their peripheral terminals. The afferent innervation of airways and lungs is organised as sensory receptor structures, of which at least seven types with a vagal origin and two with a spinal origin have been reported. In view of the recently suggested therapeutic promise of ATP antagonism… CONTINUE READING