Sensory gating impairment associated with schizophrenia persists into REM sleep.

@article{Kisley2003SensoryGI,
  title={Sensory gating impairment associated with schizophrenia persists into REM sleep.},
  author={Michael A. Kisley and Ann Olincy and Emily Robbins and Sherrie D Polk and Lawrence E. Adler and Merilyne C. Waldo and Robert Freedman},
  journal={Psychophysiology},
  year={2003},
  volume={40 1},
  pages={
          29-38
        }
}
Physiological measures of sensory gating are increasingly used to study biological factors associated with attentional dysfunction in psychiatric and neurologic patient populations. The present study was designed to assess sensory gating during rapid eye movement (REM) sleep in patients with schizophrenia, a population bearing a genetic load for gating impairment. Auditory event-related potentials (ERPs) were recorded in response to paired clicks during separate waking and overnight sleep… 

Figures and Tables from this paper

Sensory gating impairments in poor sleepers during presleep wakefulness
TLDR
Data show that poor sleepers experience enhanced sensory processing in the waking period before sleep, and further study is needed to explore sensory gating in chronic primary insomnia, sleep maintenance insomnia, and across multiple recording nights.
Early postnatal development of sensory gating
TLDR
The results demonstrate that the neural circuits underlying sensory gating are functional very early in postnatal development, and a correlation between increasing age and stronger response suppression was uncovered.
P50 Sensory Gating in Infants
TLDR
Because the auditory P50 sensory gating task is passive, it is of potential utility in the study of young infants and may provide a window into the developmental time course of attentional deficits in a variety of neuropsychiatric disorders.
Reliability of P50 auditory sensory gating measures in infants during active sleep
This study assessed reliability of auditory sensory gating in young infants from 1–4 months of age using a paired-click paradigm in which auditory ‘clicks’ were presented at an interstimulus interval
MEG does not reveal impaired sensory gating in first-episode schizophrenia
Sleep Spindles and Auditory Sensory Gating: Two Measures of Cerebral Inhibition in Preschool-Aged Children are Strongly Correlated.
TLDR
In 4-year-olds, 2 established physiological measures of sensory gating and are correlated despite being maximally active during different stages of sleep, suggesting there is an overlap in brain mechanisms underlying each gating mechanism.
Sensory gating and sensorimotor gating in medication-free obsessive-compulsive disorder patients
TLDR
It was concluded that sensorimotor and sensory gating is not impaired in drug-free OCD patients, taking into account the menstrual cycle effects in women, and hypotheses linking deficits in these inhibition paradigms and the pathogenesis of OCD are not supported.
The use of evoked potentials in sleep research.
...
...

References

SHOWING 1-10 OF 83 REFERENCES
The effect of state on sensory gating: comparison of waking, REM and non-REM sleep
Sensory gating deficits in schizophrenia: new results.
TLDR
The schizophrenic subjects manifested a significant sensory gating deficit at frontal, central, and parietal electrode placement sites, with a nonsignificant tendency for the deficit to be most prominent in the frontal areas of the brain.
Is P50 suppression a measure of sensory gating in schizophrenia?
Normalization of auditory sensory gating in schizophrenic patients after a brief period for sleep
Normalization of the auditory P50 gating deficit of schizophrenic patients after non-REM but not REM sleep
Sleep polygraphy in schizophrenia: Methodological issues
Sensory gating in chronic posttraumatic stress disorder: reduced auditory p50 suppression in combat veterans
The P50 auditory event–evoked potential in adult attention-deficit disorder: comparison with schizophrenia
...
...