Sensory fibres expressing capsaicin receptor TRPV1 in patients with rectal hypersensitivity and faecal urgency.

@article{Chan2003SensoryFE,
  title={Sensory fibres expressing capsaicin receptor TRPV1 in patients with rectal hypersensitivity and faecal urgency.},
  author={Cliburn Chan and Paul Facer and John B. Davis and Graeme Drummond Smith and Julie Egerton and C. Bountra and Norman S. Williams and P. R. Vijai Anand},
  journal={Lancet},
  year={2003},
  volume={361 9355},
  pages={385-91}
}
BACKGROUND Faecal urgency and incontinence with rectal hypersensitivity is a distressing, unexplained disorder that is inadequately treated. We aimed to determine whether expression of the heat and capsaicin receptor vanilloid receptor 1 (TRPV1 or VR1) was changed in rectal sensory fibres, and to correlate nerve fibre density with sensory abnormalities. METHODS We compared full-thickness rectal biopsy samples from nine patients with physiologically characterised rectal hypersensitivity with… CONTINUE READING