Sensory Neuropeptides, Serotonin Innervations and Personality in Women withVulvodynia

  title={Sensory Neuropeptides, Serotonin Innervations and Personality in Women withVulvodynia},
  author={S. Naess{\'e}n and J. Sundstr{\"o}m and S. Rahm},
  journal={Journal of clinical \& experimental dermatology research},
Objective: The pathophysiology of vulvadynia is still unclear. We evaluated the general innervations of the nerves, the sensory neuropeptides in the vestibular area in eighteen women with vulvadynia, aged 20-38. The same individual acted as her own control and biopsies were taken from affected and none affected areas of posterior wall of the vulval vestibule. Quantitative immunohistochemistry was performed, using antisera to the general neuronal marker protein gene product (PGP) 9.5 and to the… Expand
A Brief Context about Neuropathic Pain
Investigations have disclosed that the composition of the CD4+ T lymphocytes concerned within the maintenance of neuropathic pain-like behavior via living thing flow cytometric analysis and explored potential interactions between infiltrating CD4-T lymphocytes and funiculus interstitial tissue cells. Expand
Decision Making and its Positive Approach
The choice sciences and care hypothesis both concentrate on consideration regarding perspectives and their roots, but little is presently thought about how to enhance choice making results notwithstanding inclinations. Expand


Psychophysical evidence of nociceptor sensitization in vulvar vestibulitis syndrome
The results are compatible with the hypothesis that patients with VVS have an increased innervation and/or sensitization of thermoreceptors and nociceptors in their vestibular mucosa. Expand
Neurochemical Characterization of the Vestibular Nerves in Women with Vulvar Vestibulitis Syndrome
These findings confirm the previous theory that the free nerve endings within the epithelium are nociceptors, and Neurochemically characterize the superficial nerves in the vulvar vestibular mucosa of women with VVS. Expand
Psychological aspects of vulvar vestibulitis syndrome
There is no compelling evidence that VVS per se is associated with any particular psychological or behavioural characteristics other than the sort of difficulties in sexual functioning which might be expected with chronic vulval pain, however there is evidence for high levels of psychological distress in some samples of women with VVS being seen in secondary care. Expand
Depressive symptoms among women with vulvar dysesthesia.
Vulvar dysesthesia is associated with elevated depressive symptom severity, although not to the extent that indicates probable depressive disorder, and depressive symptoms are likely to be a measurement artifact, rather than a depressive process. Expand
Increased innervation of the vulval vestibule in patients with vulvodynia
Pain precipitated in the absence of nociceptor stimuli might be triggered by previous peripheral nerve injury, or by the release of neuronal mediators, which set off inappropriate impulses in nonmyelinated pain fibres sensitizing the dorsal horn neurones. Expand
The Major Histopathologic Characteristics in the Vulvar Vestibulitis Syndrome
The results support the existence of peripheral nerve hyperplasia in vestibular tissue obtained from patients with vulvar vestibulitis, and exclude the role of active inflammation or mast cells as probable etiologies for the vulvar Vestibular mucosa syndrome. Expand
Clinical profile of vulvodynia patients. A prospective study of 300 patients.
  • L. Sadownik
  • Medicine
  • The Journal of reproductive medicine
  • 2000
Physicians should approach management of vulvodynia using a chronic pain model that emphasizes multidisciplinary health care and "improvement" in health, rather than single interventions and cure of disease. Expand
Psychosexual characteristics of vestibulodynia couples: partner solicitousness and hostility are associated with pain.
Results suggest that although the psychosexual and relationship characteristics of partners of women with vestibulodynia are within norms, their responses may play a role in the experience of pain. Expand
Vulvar Vestibulitis Syndrome: Reliability of Diagnosis and Evaluation of Current Diagnostic Criteria
Vulvar vestibulitis can be reliably diagnosed in women with dyspareunia and can be rated and described in a consistent fashion by these women, and Erythema does not appear to be a useful diagnostic criterion. Expand
Vulvar vestibulitis syndrome: a critical review.
A pain syndrome conceptualization is suggested as the most useful approach for solving current empirical and clinical problems of Vulvar vestibulitis syndrome. Expand