Sensorimotor gating of schizophrenia patients is influenced by 5-HT2A receptor polymorphisms.

@article{Quednow2008SensorimotorGO,
  title={Sensorimotor gating of schizophrenia patients is influenced by 5-HT2A receptor polymorphisms.},
  author={Boris B. Quednow and Kai-Uwe K{\"u}hn and Rainald Moessner and Sibylle G. Schwab and Anna Schuhmacher and Wolfgang Maier and Michael Wagner},
  journal={Biological psychiatry},
  year={2008},
  volume={64 5},
  pages={434-7}
}
BACKGROUND Schizophrenia patients exhibit impairment in prepulse inhibition (PPI) of the acoustic startle response (ASR), suggesting a sensorimotor gating deficit. The serotonin-2A receptor (5-HT(2A)R) has been implicated in both the pathogenesis of schizophrenia and the PPI deficits of schizophrenia patients. Moreover, both schizophrenia and PPI are thought to be inheritable. We investigated the impact of three 5-HT(2A)R polymorphisms (A-1438G, T102C, H452Y) on PPI in schizophrenia patients… CONTINUE READING
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