Sensorimotor gating in boys with Tourette's syndrome and ADHD: Preliminary results

@article{Castellanos1996SensorimotorGI,
  title={Sensorimotor gating in boys with Tourette's syndrome and ADHD: Preliminary results},
  author={F. Xavier Castellanos and Edward J Fine and Debra L. Kaysen and Wendy L Marsh and Mark Hallett},
  journal={Biological Psychiatry},
  year={1996},
  volume={39},
  pages={33-41}
}
Deficits in sensorimotor gating, defined by prepulse inhibition (PPI), have been associated with subcortical dopaminergic overactivity in animal and clinical studies. Utilizing supraorbital nerve electrical stimulation, we produced adequate blink responses and measured decreases in amplitude resulting from electric prestimuli just above sensory threshold. Seven boys comorbid for attention-deficit hyperactivity disorder (ADHD) and a tic disorder had significantly reduced PPI, compared to 14… CONTINUE READING
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