Sensorimotor gating and habituation in antipsychotic-naive, first-episode schizophrenia patients before and after 6 months' treatment with quetiapine.

@article{Aggernaes2010SensorimotorGA,
  title={Sensorimotor gating and habituation in antipsychotic-naive, first-episode schizophrenia patients before and after 6 months' treatment with quetiapine.},
  author={Bodil Aggernaes and Birte Y. Glenthoj and Bjorn H. Ebdrup and Hans Rasmussen and Henrik Lublin and Bob Oranje},
  journal={The international journal of neuropsychopharmacology},
  year={2010},
  volume={13 10},
  pages={1383-95}
}
Impaired prepulse inhibition of the startle reflex (PPI) in schizophrenia has been replicated in many studies. However, previous results may have been influenced by course of illness, and antipsychotic medication. Studies on antipsychotic-naive, first-episode schizophrenia patients are lacking, since these patients are so difficult to recruit. Furthermore, longitudinal studies are few, and their results are inconsistent: some results indicating a reduction of PPI deficits by treatment with… CONTINUE READING