Sensorimotor deficits in a unilateral intrastriatal 6-OHDA partial lesion model of Parkinson's disease in marmoset monkeys.

@article{Eslamboli2003SensorimotorDI,
  title={Sensorimotor deficits in a unilateral intrastriatal 6-OHDA partial lesion model of Parkinson's disease in marmoset monkeys.},
  author={Andisheh Eslamboli and Harry F. Baker and Rosalind M. Ridley and Lucy E. Annett},
  journal={Experimental neurology},
  year={2003},
  volume={183 2},
  pages={418-29}
}
Animal studies investigating the efficacy of neurotrophic factors as treatments for Parkinson's disease (PD) ideally require partial dopamine (DA) lesion models. The intrastriatal 6-hydroxydopamine (6-OHDA) lesion model may be suitable for this purpose. Although this model has been well characterized in rodents, it has not previously been used in monkeys. The goal of the present study was to characterize the behavioral effects of unilateral injections of 6-OHDA in the basal ganglia of common… CONTINUE READING

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