Sensor domains encoded in Bacillus anthracis virulence plasmids prevent sporulation by hijacking a sporulation sensor histidine kinase.

@article{White2006SensorDE,
  title={Sensor domains encoded in Bacillus anthracis virulence plasmids prevent sporulation by hijacking a sporulation sensor histidine kinase.},
  author={Andrea Kirsten White and James A. Hoch and Marcin Grynberg and Adam Godzik and Marta Perego},
  journal={Journal of bacteriology},
  year={2006},
  volume={188 17},
  pages={6354-60}
}
Anthrax toxin and capsule, determinants for successful infection by Bacillus anthracis, are encoded on the virulence plasmids pXO1 and pXO2, respectively. Each of these plasmids also encodes proteins that are highly homologous to the signal sensor domain of a chromosomally encoded major sporulation sensor histidine kinase (BA2291) in this organism. B. anthracis Sterne overexpressing the plasmid pXO2-61-encoded signal sensor domain exhibited a significant decrease in sporulation that was… CONTINUE READING

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