Sensor combination and chemometric modelling for improved process monitoring in recombinant E. coli fed-batch cultivations.


The key objective for the optimisation of recombinant protein production in bacteria is to optimize the exploitation of the host cell's synthesis potential. Recent studies show that the novel concept of transcription rate control allows the tuning of recombinant gene expression in relation to the metabolic capacity of the host cell. To adjust the inducer… (More)