Sensor combination and chemometric modelling for improved process monitoring in recombinant E. coli fed-batch cultivations.

@article{Clementschitsch2005SensorCA,
  title={Sensor combination and chemometric modelling for improved process monitoring in recombinant E. coli fed-batch cultivations.},
  author={Franz Clementschitsch and Kern J{\"u}rgen and P{\"o}tschacher Florentina and Bayer Karl},
  journal={Journal of biotechnology},
  year={2005},
  volume={120 2},
  pages={183-96}
}
The key objective for the optimisation of recombinant protein production in bacteria is to optimize the exploitation of the host cell's synthesis potential. Recent studies show that the novel concept of transcription rate control allows the tuning of recombinant gene expression in relation to the metabolic capacity of the host cell. To adjust the inducer-biomass ratio to a tolerable level, real-time knowledge about key process variables is paramount. Since there are no reliable online-sensors… CONTINUE READING

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