Sensitizing soluble guanylyl cyclase to become a highly CO-sensitive enzyme.

  title={Sensitizing soluble guanylyl cyclase to become a highly CO-sensitive enzyme.},
  author={Andreas Friebe and Guenter Schultz and Doris Koesling},
  journal={The EMBO journal},
  volume={15 24},
It took at least a decade to realize that the toxic gas NO is the physiological activator of soluble guanylyl cyclase (sGC), thereby acting as a signaling molecule in the nervous and cardiovascular systems. Despite its rather poor sGC-activating property, CO has also been implicated as a physiological stimulator of sGC in neurotransmission and vasorelaxation. Here, we establish YC-1 as a novel NO-independent sGC activator that potentiates both CO- and NO-induced sGC stimulation. As this… CONTINUE READING
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