Sensitization to mechanical stimulation by inflammatory mediators and by mild burn in canine visceral nociceptors in vitro.


Hyperalgesia to mechanical stimulation and heat is commonly observed in inflamed conditions. Although sensitization to heat is well documented and its mechanism has also been well studied, it remains unclear whether and how nociceptors are sensitized to mechanical stimulation. Therefore we conducted in vitro investigation of which inflammatory mediators… (More)


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