Sensitization to locomotor effects of methylphenidate in the rat.

  title={Sensitization to locomotor effects of methylphenidate in the rat.},
  author={Osvaldo Gaytan and S Al-rahim and Alan C. Swann and Nachum Dafny},
  journal={Life sciences},
  volume={61 8},
A computerized activity monitoring system was used to investigate whether repeated exposure to methylphenidate (MPD) could produce sensitization to its locomotor effects in the rat. Male Sprague-Dawley rats were housed in test cages and activity was recorded continuously for 16 days as follows: Baseline activity (Day 1-2), recording following saline injection (Day 3), MPD Challenge Doses--either 0.6, 2.5, or 10 mg/kg of MPD (Day 4); five days of a repeated dose of 2.5 mg/kg (Day 5-9), five… CONTINUE READING

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