Sensitization to doxorubicin resistance in breast cancer cell lines by tamoxifen and megestrol acetate.

Abstract

Acquired drug resistance is a major factor in the failure of doxorubicin-based chemotherapy in breast cancer. We determined the ability of megestrol acetate and/or tamoxifen to reverse doxorubicin drug resistance in a doxorubicin-resistant breast cancer line (the human MCF-7/ADR). The cytotoxicity of doxorubicin, megestrol acetate, and/or tamoxifen was… (More)

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Cite this paper

@article{Panasci1996SensitizationTD, title={Sensitization to doxorubicin resistance in breast cancer cell lines by tamoxifen and megestrol acetate.}, author={Lwrence C Panasci and Bertrand Jean-Claude and Dan Vasilescu and A. Mustafa and Simona Irina Damian and Z. Dami{\'a}n and E. Georges and Z. Liu and Gerry Batist and Brian R. Leyland-Jones}, journal={Biochemical pharmacology}, year={1996}, volume={52 7}, pages={1097-102} }