Sensitization to amphetamine occurs simultaneously at immune level and in met-enkephalin of the nucleus accumbens and spleen: an involved NMDA glutamatergic mechanism.

@article{Assis2009SensitizationTA,
  title={Sensitization to amphetamine occurs simultaneously at immune level and in met-enkephalin of the nucleus accumbens and spleen: an involved NMDA glutamatergic mechanism.},
  author={Mar{\'i}a Amparo Assis and Cristian Hansen and Victoria A Lux-Lantos and Liliana Marina Cancela},
  journal={Brain, behavior, and immunity},
  year={2009},
  volume={23 4},
  pages={464-73}
}
Administration of psychostimulants can elicit a sensitized response to the stimulating and reinforcing properties of the drugs, although there is scarce information regarding their effects at immune level. We previously demonstrated that an acute exposure to amphetamine (5 mg/kg, i.p.) induced an inhibitory effect on the splenic T-cell proliferative response, along with an increase in met-enkephalin at limbic and immune levels, 4 days following drug administration. In this study, we evaluated… CONTINUE READING