Sensitization of vascular smooth muscle cell to TNF-alpha-mediated death in the presence of palmitate.

@article{Rho2007SensitizationOV,
  title={Sensitization of vascular smooth muscle cell to TNF-alpha-mediated death in the presence of palmitate.},
  author={Mun-Chual Rho and Kyeong Ah Lee and Sun Mi Kim and Chang Sik Lee and Min Jeong Jang and Young Kook Kim and Hyun Sun Lee and Yung Hyun Choi and Byung Yong Rhim and Koanhoi Kim},
  journal={Toxicology and applied pharmacology},
  year={2007},
  volume={220 3},
  pages={311-9}
}
Saturated free fatty acids (FFAs), including palmitate, can activate the intrinsic death pathway in cells. However, the relationship between FFAs and receptor-mediated death pathway is still unknown. In this study, we have investigated whether FFAs are able to trigger receptor-mediated death. In addition, to clarify the mechanisms responsible for the activation, we examined the biochemical changes in dying vascular smooth muscle cell (VSMC) and the effects of various molecules to the receptor… CONTINUE READING

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Tumor Necrosis FactorsGene product plays role in biological processCell Death
To the best of our knowledge , this study is the first report to demonstrate the activation of TNF - alpha - mediated cell death in the presence of palmitate .
Palmitate inhibited an increase of TNF - alpha - mediated nuclear factor kappa B ( NF - kappaB ) activity , the survival pathway activated by the cytokine , by hindering the translocation of the NF - kappaB subunit of p65 from the cytosol into the nucleus .
Tumor necrosis factor ( TNF)-alpha - mediated VSMC death occurred in the presence of sub - cytotoxic concentration of palmitate as determined by assessing viability and DNA degradation , while the cytokine did not influence VSMC viability in the presence of oleate .
Palmitate inhibited an increase of TNF - alpha - mediated nuclear factor kappa B ( NF - kappaB ) activity , the survival pathway activated by the cytokine , by hindering the translocation of the NF - kappaB subunit of p65 from the cytosol into the nucleus .
Tumor necrosis factor ( TNF)-alpha - mediated VSMC death occurred in the presence of sub - cytotoxic concentration of palmitate as determined by assessing viability and DNA degradation , while the cytokine did not influence VSMC viability in the presence of oleate .
Tumor necrosis factor ( TNF)-alpha - mediated VSMC death occurred in the presence of sub - cytotoxic concentration of palmitate as determined by assessing viability and DNA degradation , while the cytokine did not influence VSMC viability in the presence of oleate .
Tumor necrosis factor ( TNF)-alpha - mediated VSMC death occurred in the presence of sub - cytotoxic concentration of palmitate as determined by assessing viability and DNA degradation , while the cytokine did not influence VSMC viability in the presence of oleate .
Palmitate inhibited an increase of TNF - alpha - mediated nuclear factor kappa B ( NF - kappaB ) activity , the survival pathway activated by the cytokine , by hindering the translocation of the NF - kappaB subunit of p65 from the cytosol into the nucleus .
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