Sensitization of unmyelinated sensory fibers of the joint nerve to mechanical stimuli by interleukin-6 in the rat: an inflammatory mechanism of joint pain.

@article{Brenn2007SensitizationOU,
  title={Sensitization of unmyelinated sensory fibers of the joint nerve to mechanical stimuli by interleukin-6 in the rat: an inflammatory mechanism of joint pain.},
  author={Daniel Brenn and Frank J Richter and H. -G. Schaible},
  journal={Arthritis and rheumatism},
  year={2007},
  volume={56 1},
  pages={351-9}
}
OBJECTIVE Pain during mechanical stimulation of the joint and spontaneous pain are major symptoms of arthritis. An important neuronal process of mechanical hypersensitivity of the joint is the sensitization of thin myelinated Adelta fibers and unmyelinated C fibers innervating the joint. Because interleukin-6 (IL-6) is a major inflammatory mediator, we investigated whether this cytokine has the potential to sensitize joint afferents to mechanical stimuli. METHODS In electrophysiologic… CONTINUE READING