Sensitization of tumor cells to fas killing through overexpression of heat-shock transcription factor 1.

@article{Xia2000SensitizationOT,
  title={Sensitization of tumor cells to fas killing through overexpression of heat-shock transcription factor 1.},
  author={Weiling Xia and Richard Voellmy and Neil L. Spector},
  journal={Journal of cellular physiology},
  year={2000},
  volume={183 3},
  pages={425-31}
}
Activation of the heat-shock or stress response is generally considered a cytoprotective response to heat or other proteotoxic stresses. In mammalian cells, stress-induced transcription of heat-shock genes is regulated by heat-shock transcription factor 1 (HSF1). We now show that activation of the Fas death receptor transactivates HSF1 in HeLa cells, a Fas-expressing cervical carcinoma line. Whereas HSF1 is constitutively expressed in a non-DNA-binding, transcriptionally inactive state… CONTINUE READING

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