Sensitization of trigeminal caudalis neuronal responses to intraoral acid and salt stimuli and desensitization by nicotine.

@article{Sudo2002SensitizationOT,
  title={Sensitization of trigeminal caudalis neuronal responses to intraoral acid and salt stimuli and desensitization by nicotine.},
  author={Satoko Sudo and Makoto Sudo and Christopher T. Simons and Jean Marc Dessirier and Earl E. Carstens},
  journal={Pain},
  year={2002},
  volume={98 3},
  pages={277-86}
}
In human studies, repeated intraoral application of strong acidic or salt stimuli induces irritation that progressively increases across trials (sensitization), whereas irritation elicited by nicotine progressively decreases (desensitization). We investigated whether nociceptive neurons in trigeminal subnucleus caudalis (Vc) exhibit increasing or decreasing patterns of firing to the intraoral application of these irritants. In rats anesthetized with halothane and thiopental, single-unit… CONTINUE READING

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