Sensitization of the Locomotor Response to Psychostimulants after Repeated Opiate Exposure: Role of the Nucleus Accumbens

@article{Cunningham1997SensitizationOT,
  title={Sensitization of the Locomotor Response to Psychostimulants after Repeated Opiate Exposure: Role of the Nucleus Accumbens},
  author={S Tiffany Cunningham and Marianne Finn and Ann E. Kelley},
  journal={Neuropsychopharmacology},
  year={1997},
  volume={16},
  pages={147-155}
}
The following experiments were performed to ascertain the role of the nucleus accumbens in opiate-dopamine interactions using measures of locomotor activity. Three separate experiments were carried out. In Experiment 1, rats received systemic morphine (10 mg/kg IP) or saline (1 ml/kg IP) every other day for 5 days, followed by systemic amphetamine (1.5 mg/kg) 48 hours following the fifth injection. Animals in the morphine pretreatment group exhibited a sensitized locomotor response to… CONTINUE READING

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