Sensitization of prepulse inhibition deficits by repeated administration of dizocilpine

  title={Sensitization of prepulse inhibition deficits by repeated administration of dizocilpine},
  author={Brigitte Schulz and Markus Fendt and Vera Pedersen and Michael Koch},
Rationale: Repeated administration of psychoactive drugs results in a progressive enhancement of the behavioral effects of these compounds, a phenomenon termed sensitization. Objective: We tested whether repeated administration of the non-competitive NMDA receptor antagonist dizocilpine (MK-801) induces sensitization of the disruptive effects of this compound on prepulse inhibition (PPI) of startle. Methods: Rats received nine daily IP injections of 0.1 mg/kg MK-801 in the startle cage and were… CONTINUE READING


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Characterization of MK-801-induced behavior as a putative rat model of psychosis.

The Journal of pharmacology and experimental therapeutics • 1999

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