Sensitization of ovarian carcinoma cells to Bcl-xL-targeting strategies through indirect modulation of Mcl-1 activity by MR22388, a molecule of the tripentone family

@article{Tomasina2013SensitizationOO,
  title={Sensitization of ovarian carcinoma cells to Bcl-xL-targeting strategies through indirect modulation of Mcl-1 activity by MR22388, a molecule of the tripentone family},
  author={J. Tomasina and A. Malzert‐Fr{\'e}on and F. Giffard and {\'E}. Brotin and M. Louis and E. Abeilard and S. Rault and P. Gauduchon and L. Poulain},
  journal={Journal of Ovarian Research},
  year={2013},
  volume={6},
  pages={38 - 38}
}
  • J. Tomasina, A. Malzert‐Fréon, +6 authors L. Poulain
  • Published 2013
  • Medicine
  • Journal of Ovarian Research
  • BackgroundOur work has been carried out in the context of the therapeutic failure in ovarian carcinoma, which remains the leading cause of death by gynecologic malignancy. In these tumours, recurrence and subsequent acquired chemoresistance constitute major hurdles to successful therapy. Here we studied the interest of a member of the tripentone chemical family, MR22388, for the treatment of chemoresistant ovarian cancer cells.FindingsMR22388 activity has been assessed in vitro on cisplatin… CONTINUE READING
    3 Citations

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