Sensitization of enteric neurons to morphine by HIV-1 Tat protein.

  title={Sensitization of enteric neurons to morphine by HIV-1 Tat protein.},
  author={Sylvia Fitting and Joy Ngwainmbi and Minho Kang and Fayez A Khan and David L. Stevens and William L. Dewey and Pamela E Knapp and Kurt F Hauser and Hamid I. Akbarali},
  journal={Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society},
  volume={27 4},
BACKGROUND Gastrointestinal (GI) dysfunction is a major cause of morbidity in acquired immunodeficiency syndrome (AIDS). HIV-1-induced neuropathogenesis is significantly enhanced by opiate abuse, which increases proinflammatory chemokine/cytokine release, the production of reactive species, glial reactivity, and neuronal injury in the central nervous system. Despite marked interactions in the gut, little is known about the effects of HIV-1 in combination with opiate use on the enteric nervous… CONTINUE READING
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