Sensitization of central trigeminovascular neurons: blockade by intravenous naproxen infusion.

@article{Jakubowski2007SensitizationOC,
  title={Sensitization of central trigeminovascular neurons: blockade by intravenous naproxen infusion.},
  author={Moshe Jakubowski and Dan Levy and Vanessa M Kainz and X-C Zhang and B{\'e}la Kosaras and Rami Burstein},
  journal={Neuroscience},
  year={2007},
  volume={148 2},
  pages={573-83}
}
We have previously observed that migraine attacks impervious to triptan therapy were readily terminated by subsequent i.v. administration of the non-steroidal anti-inflammatory drug (NSAID) ketorolac. Since such attacks were associated with periorbital allodynia--a symptom of central sensitization--we examined whether infusion of the NSAID naproxen can block sensitization of central trigeminovascular neurons in the medullary dorsal horn, using in vivo single-unit recording in the rat. Topical… CONTINUE READING
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