Sensitization of breast cancer cells to radiation by trastuzumab.

@article{Liang2003SensitizationOB,
  title={Sensitization of breast cancer cells to radiation by trastuzumab.},
  author={K X Liang and Yang Lu and Weidong Jin and K. Kian Ang and Luka Milas and Zhen Fan},
  journal={Molecular cancer therapeutics},
  year={2003},
  volume={2 11},
  pages={1113-20}
}
HER2, a member of the human epidermal growth factor (EGF) receptor family, not only plays important roles in the progression of breast cancer tumorigenesis and metastasis, but may protect cancer cells from conventional cytotoxic therapies as well. In the current study, we evaluated the effect of targeting HER2 on radiosensitization of human breast cancer cells. Using six breast cancer cell lines with various levels of HER2 (BT474, SKBR3, MDA453, MCF7, ZR75B, and MDA468), we found that… CONTINUE READING

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