Sensitization of a tumor, but not normal tissue, to the cytotoxic effect of ionizing radiation using Panax notoginseng extract.

@article{Chen2001SensitizationOA,
  title={Sensitization of a tumor, but not normal tissue, to the cytotoxic effect of ionizing radiation using Panax notoginseng extract.},
  author={F. D. Chen and Manli Wu and Hsin-Ell Wang and Janice Jin Hwang and C. Y. Hong and Y T Huang and S. H. Yen and Y H Ou},
  journal={The American journal of Chinese medicine},
  year={2001},
  volume={29 3-4},
  pages={517-24}
}
The aim of the present study was to investigate any sensitization effect of the Panax notoginseng extract (PNE) and the purified Saponin (Rb1) on the radiation response of an experimental tumor (KHT sarcoma) in mice, in comparison with any effects on a normal tissue (bone marrow). PNE at a concentration of 0.1-100 mg/kg produced an increase in tumor radiosensitivity. The sensitization effect was maximal at 10 mg/kg and at 30 minutes after injection. Higher doses were toxic to the bone marrow… CONTINUE READING