Sensitization of T lymphocytes in vitro by syngeneic macrophages fed with tumor antigens.

@article{Treves1976SensitizationOT,
  title={Sensitization of T lymphocytes in vitro by syngeneic macrophages fed with tumor antigens.},
  author={Abraham J. Treves and Bilha Schechter and Irun R. Cohen and Michael Feldman},
  journal={Journal of immunology},
  year={1976},
  volume={116 4},
  pages={1059-64}
}
We investigated the interaction between T lymphocytes and macrophages in the vitro sensitization of lymphocytes against tumor cells. Spleen cells were sensitized in vitro by syngeneic peritoneal macrophages that had been fed with cell-free antigen preparation of syngeneic tumor cells. The sensitized T lymphocytes acquired specific cytotoxic cells. The sensitized T lymphocytes acquired specific cytotoxic activity in vitro and the capacity to inhingeneic fibroblasts, or the antigen preparation by… CONTINUE READING