Sensitization of DNA damage–induced apoptosis by the proteasome inhibitor PS-341 is p53 dependent and involves target proteins 14-3-3S and survivin

Abstract

Proteasome inhibition following DNA damage results in the synergistic induction of apoptosis via a nuclear factor-KB– independent mechanism. In this study, we identify the role of p53 in mediating apoptosis by the sequence-specific treatment involving the DNA-damaging, topoisomerase I–targeting drug SN-38 followed by the proteasome inhibitor PS-341 (SN-38… (More)

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@inproceedings{Vaziri2005SensitizationOD, title={Sensitization of DNA damage–induced apoptosis by the proteasome inhibitor PS-341 is p53 dependent and involves target proteins 14-3-3S and survivin}, author={Susan A. J. Vaziri and Jason Hill and Kenichi Chikamori and Dale R. Grabowski and Nagio Takigawa and Mamta Chawla-Sarkar and Lisa R. Rybicki and Andrei V. Gudkov and Tarek M. Mekhail and Ronald M. Bukowski and Mahrukh K. Ganapathi and Ram N. Ganapathi}, year={2005} }