Sensitization of Chinese hamster ovary cells to heat shock by alpha-difluoromethylornithine.

Abstract

When exposed to alpha-difluoromethylornithine (DFMO), an inhibitor of polyamine biosynthesis, Chinese hamster ovary cells become increasingly sensitive to the cytotoxic effects of elevated temperatures (D.J.M. Fuller and E.W. Gerner, Cancer Res., 42:5046-5049, 1982). This sensitization becomes marked at times greater than 24 h after drug removal, and by 48… (More)

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@article{Fuller1987SensitizationOC, title={Sensitization of Chinese hamster ovary cells to heat shock by alpha-difluoromethylornithine.}, author={David J. M. Fuller and Eugene W. Gerner}, journal={Cancer research}, year={1987}, volume={47 3}, pages={816-20} }