Sensitization of Cells Overexpressing Multidrug-Resistant Proteins by Pluronic P85

Abstract

Purpose. This study evaluated the chemosensitizing effects of Pluronic P85 (P85) on cells expressing multidrug resistance-associated proteins, MRP1 and MRP2. Methods. Cell models included MRP1- and MRP2-transfected MDCKII cells as well as doxorubicin-selected COR-L23/R cells overexpressing MRP1. Effects of P85 on cellular accumulation and cytotoxicity of… (More)
DOI: 10.1023/A:1026179132599

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