Sensitization of Burkholderia cepacia to antibiotics by cationic drugs.

  title={Sensitization of Burkholderia cepacia to antibiotics by cationic drugs.},
  author={J M Rajyaguru and Milosz Muszynski},
  journal={The Journal of antimicrobial chemotherapy},
  volume={41 2},
Chlorpromazine and prochlorperazine have previously been shown to enhance the susceptibility of Burkholderia cepacia to aminoglycosides. To screen other non-antibiotic drugs containing similar amine (-N-CH3) groups, we examined a range of such agents that are in current clinical use for the treatment of non-infectious diseases, in combination with antibiotics that are ineffective against B. cepacia. At a concentration of 0.2 mM, theobromine, theophylline, trifluoperazine, fluophenazine and… CONTINUE READING

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