Sensitization for anticancer drug-induced apoptosis by the chemopreventive agent resveratrol

@article{Fulda2004SensitizationFA,
  title={Sensitization for anticancer drug-induced apoptosis by the chemopreventive agent resveratrol},
  author={Simone Fulda and K -M Debatin},
  journal={Oncogene},
  year={2004},
  volume={23},
  pages={6702-6711}
}
Current attempts to improve the survival of cancer patients largely depend on strategies to target tumor cell resistance. Naturally occurring dietary compounds such as resveratrol have gained considerable attention as cancer chemopreventive agents. Here, we report that resveratrol acts as potent sensitizer for anticancer drug-induced apoptosis by inducing cell cycle arrest, which in turn resulted in survivin depletion. Concomitant analysis of cell cycle and apoptosis revealed that pretreatment… CONTINUE READING